Ab42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein and ErbB-4 receptor and signaling through the APP intracellular domain*

* This work was supported by NIH Grant AG 20206 (to T. E. G. and E. H. K.), an Emmy Noether fellowship from the Deutsche Forschungsgemeinschaft (to S. W.) and a fellowship from the John Douglas French Alzheimer’s Foundation (to J. E.). ‡ Current address: Johannes Gutenberg University, 55099 Mainz, Germany ** To whom correspondence should be addressed: Dr. Sascha Weggen, Department of Neurosciences, University of California San Diego, La Jolla, CA 921093-0691 Tel.: 858-822-1025; Fax: 858-822-1021; E-mail: [email protected]